TY - JOUR T1 - Effect modification of perinatal exposure to air pollution and childhood asthma incidence JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01884-2017 VL - 51 IS - 3 SP - 1701884 AU - Éric Lavigne AU - Marc-André Bélair AU - Daniel Rodriguez Duque AU - Minh T. Do AU - David M. Stieb AU - Perry Hystad AU - Aaron van Donkelaar AU - Randall V. Martin AU - Daniel L. Crouse AU - Eric Crighton AU - Hong Chen AU - Richard T. Burnett AU - Scott Weichenthal AU - Paul J. Villeneuve AU - Teresa To AU - Jeffrey R. Brook AU - Markey Johnson AU - Sabit Cakmak AU - Abdool S. Yasseen III AU - Mark Walker Y1 - 2018/03/01 UR - http://erj.ersjournals.com/content/51/3/1701884.abstract N2 - Perinatal exposure to ambient air pollution has been associated with childhood asthma incidence; however, less is known regarding the potential effect modifiers in this association. We examined whether maternal and infant characteristics modified the association between perinatal exposure to air pollution and development of childhood asthma.761 172 births occurring between 2006 and 2012 were identified in the province of Ontario, Canada. Associations between exposure to ambient air pollutants and childhood asthma incidence (up to age 6 years) were estimated using Cox regression models.110 981 children with asthma were identified. In models adjusted for postnatal exposures, second-trimester exposures to particulate matter with a 50% cut-off aerodynamic diameter ≤2.5 μm (hazard ratio (HR) per interquartile range (IQR) increase 1.07, 95% CI 1.06–1.09) and nitrogen dioxide (HR per IQR increase 1.06, 95% CI 1.03–1.08) were associated with childhood asthma development. Enhanced impacts were found among children born to mothers with asthma, who smoked during pregnancy or lived in urban areas during pregnancy, males and children born preterm or of low birthweight.Prenatal exposure to air pollution may have a differential impact on the risk of asthma development, according to maternal and infant characteristics.Maternal asthma enhances the effect of air pollution during pregnancy on the risk of developing asthma in children http://ow.ly/eeWp30hSsIb ER -