RT Journal Article
SR Electronic
T1 The effect of text messaging on latent tuberculosis treatment adherence: a randomised controlled trial
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1701488
DO 10.1183/13993003.01488-2017
VO 51
IS 2
A1 James C. Johnston
A1 Mia L. van der Kop
A1 Kirsten Smillie
A1 Gina Ogilvie
A1 Fawziah Marra
A1 Mohsen Sadatsafavi
A1 Kamila Romanowski
A1 Matthew A. Budd
A1 Jan Hajek
A1 Victoria Cook
A1 Richard T. Lester
YR 2018
UL http://erj.ersjournals.com/content/51/2/1701488.abstract
AB There is limited high-quality evidence available to inform the use of text messaging to improve latent tuberculosis infection (LTBI) treatment adherence.We performed a parallel, randomised controlled trial at two sites to assess the effect of a two-way short message service on LTBI adherence. We enrolled adults initiating LTBI therapy from June 2012 to September 2015 in British Columbia, Canada. Participants were randomised in a 1:1 ratio to standard LTBI treatment (control) or standard LTBI treatment plus two-way weekly text messaging (intervention). The primary outcome was treatment completion, defined as taking ≥80% prescribed doses within 12 months (isoniazid) or 6 months (rifampin) of enrolment. The trial was unblinded except for the data analyst.A total of 358 participants were assigned to the intervention (n=170) and control (n=188) arms. In intention-to-treat analysis, the proportion of participants completing LTBI therapy in the intervention and control arms was 79.4% and 81.9%, respectively (RR 0.97, 95% CI 0.88–1.07; p=0.550). Results were similar for pre-specified secondary end-points, including time-to-completion of LTBI therapy, completion of >90% of prescribed LTBI doses and health-related quality of life.Weekly two-way text messaging did not improve LTBI completion rates compared to standard LTBI care; however, completion rates were high in both treatment arms.Weekly two-way text messaging did not improve latent tuberculosis treatment completion in a high-resource setting http://ow.ly/9gLA30hzSlE