RT Journal Article
SR Electronic
T1 Effect modification of perinatal exposure to air pollution and childhood asthma incidence
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1701884
DO 10.1183/13993003.01884-2017
A1 Éric Lavigne
A1 Marc-André Bélair
A1 Daniel Rodriguez Duque
A1 Minh T. Do
A1 David M. Stieb
A1 Perry Hystad
A1 Aaron van Donkelaar
A1 Randall V. Martin
A1 Daniel L. Crouse
A1 Eric Crighton
A1 Hong Chen
A1 Richard T. Burnett
A1 Scott Weichenthal
A1 Paul J. Villeneuve
A1 Teresa To
A1 Jeffrey R. Brook
A1 Markey Johnson
A1 Sabit Cakmak
A1 Abdool S. Yasseen III
A1 Mark Walker
YR 2018
UL http://erj.ersjournals.com/content/early/2018/01/18/13993003.01884-2017.abstract
AB Perinatal exposure to ambient air pollution has been associated with childhood asthma incidence, however, less is known regarding the potential effect modifiers in this association. We examined whether maternal and infant characteristics modified the association between perinatal exposure to air pollution and development of childhood asthma.761 172 births occurring between 2006 and 2012 were identified in the province of Ontario, Canada. Associations between exposure to ambient air pollutants and childhood asthma incidence (up to age 6) were estimated using Cox regression models.110,981 children with asthma were identified. In models adjusted for postnatal exposures, second trimester exposures to particulate matter with a diameter ≤2.5 μm (PM2.5) (Hazard Ratio (HR) per interquartile (IQR) increase=1.07, 95% CI: 1.06–1.09) and nitrogen dioxide (NO2) (HR per IQR increase=1.06, 95% CI: 1.03–1.08) were associated with childhood asthma development. Enhanced impacts were found among children born to mothers with asthma, those who smoked during pregnancy, boys, those born preterm, of low birth weight and among those born to mothers living in urban areas during pregnancy.Prenatal exposure to air pollution may have a differential impact on the risk of asthma development according to maternal and infant characteristics.Maternal asthma enhances the effect of air pollution during pregnancy on the risk of developing asthma in childrenFootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Lavigne has nothing to disclose.Conflict of interest: Marc-André BelairConflict of interest: Daniel Rodriguez DuqueConflict of interest: Minh T. DoConflict of interest: David M. StiebConflict of interest: Perry HystadConflict of interest: Aaron van DonkelaarConflict of interest: Randall V. MartinConflict of interest: Daniel L. CrouseConflict of interest: Eric CrightonConflict of interest: Hong ChenConflict of interest: Richard T. BurnettConflict of interest: Scott WeichenthalConflict of interest: Paul J. VilleneuveConflict of interest: Teresa ToConflict of interest: Jeffrey R. BrookConflict of interest: Markey JohnsonConflict of interest: Sabit CakmakConflict of interest: Abdool S. YasseenConflict of interest: Mark Walker