TY - JOUR T1 - Dual responses of CD14 methylation to distinct environments: a role in asthma and allergy JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01228-2017 VL - 50 IS - 6 SP - 1701228 AU - Yong Song AU - Siew-Kim Khoo AU - Khui Hung Lee AU - Mika Mäkelä AU - Tari Haahtela AU - Peter LeSouëf AU - Guicheng (Brad) Zhang Y1 - 2017/12/01 UR - http://erj.ersjournals.com/content/50/6/1701228.abstract N2 - Gene–environment interactions are believed to cause an increased prevalence of asthma and allergic diseases in Western Countries, in comparison to Eastern Countries. To date, research has been inconclusive about which specific genetic and environmental risk factors are important, how the epigenetics/genetics interact with the environment, and which pathogenic mechanisms underlie the development of asthma and allergy. Inconsistencies in research outcomes are mainly attributed to substantial variations in genetic backgrounds and environmental conditions between different populations. Furthermore, a poor understanding of epigenetics might partially account for the observed disparities.This study shows that CD14 DNA methylation is differentially regulated by environmental factors http://ow.ly/zlla30gxNWW ER -