RT Journal Article
SR Electronic
T1 Novel magnetic resonance technique for functional imaging of cystic fibrosis lung disease
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1701464
DO 10.1183/13993003.01464-2017
VO 50
IS 6
A1 Sylvia Nyilas
A1 Grzegorz Bauman
A1 Gregor Sommer
A1 Enno Stranzinger
A1 Orso Pusterla
A1 Urs Frey
A1 Insa Korten
A1 Florian Singer
A1 Carmen Casaulta
A1 Oliver Bieri
A1 Philipp Latzin
YR 2017
UL http://erj.ersjournals.com/content/50/6/1701464.abstract
AB Lung function tests are commonly used to monitor lung disease in cystic fibrosis (CF). While practical, they cannot locate the exact origin of functional impairment. Contemporary magnetic resonance imaging (MRI) techniques provide information on the location of disease but the need for contrast agents constrains their repeated application. We examined the correlation between functional MRI, performed without administration of contrast agent, and lung clearance index (LCI) from nitrogen multiple-breath washout (N2-MBW).40 children with CF (median (range) age 12.0 (6–18) years) and 12 healthy age-matched controls underwent functional and structural MRI and lung function tests on the same day. Functional MRI provided semiquantitative measures of perfusion (RQ) and ventilation (RFV) impairment as percentages of affected lung volume. Morphological MRI was evaluated using CF-specific scores. LCI measured global ventilation inhomogeneity.MRI detected functional impairment in CF: RFV 19–38% and RQ 16–35%. RFV and RQ correlated strongly with LCI (r=0.76, p<0.0001 and r=0.85, p<0.0001, respectively), as did total morphology score (r=0.81, p<0.0001). All indices differed significantly between patients with CF and healthy controls (p<0.001).Noninvasive functional MRI is a promising method to detect and visualise perfusion and ventilation impairment in CF without the need for contrast agents.New functional MRI without the need for contrast agents correlates strongly with ventilation inhomogeneity in CF http://ow.ly/emo930eQJ67