TY - JOUR T1 - Late Breaking Abstract - An interim report on the detection in blood of autoantibodies to tumour antigens as a case-finding method in lung cancer using the EarlyCDT®-Lung Test in Scotland (ECLS) JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/1393003.congress-2017.OA1471 VL - 50 IS - suppl 61 SP - OA1471 AU - Francis Sullivan AU - Stuart Schembri Y1 - 2017/09/01 UR - http://erj.ersjournals.com/content/50/suppl_61/OA1471.abstract N2 - ECLS aims to assess the effectiveness of the EarlyCDT®-Lung Test in increasing early stage lung cancer detection. If successful, this would reduce the rate of late stage presentation compared to standard practice. The study assesses cost-effectiveness, the impact of the test on quality of life and psychological state.Design: An RCT involving 12 210 participants recruited through primary care and community based recruitment strategies in the most socioeconomically deprived areas of Scotland. Adults aged 50–75 who have a 1-2% risk of developing lung cancer over the next 24 months were eligible to participate. These are defined as those who are, current or former cigarette smokers with at least 20 pack-years, or have a history of cigarette smoking less than 20 pack-years plus an immediate family history of lung cancer which. Participants were healthy enough to undergo curative treatment. If a test is positive the participant has a baseline low dose Computerised Tomography scan and 6 monthly LDCT follow up .Individuals with abnormalities as classified by a radiology/respiratory physician are followed up over the study period or referred for clinical care as appropriate. All individuals entering the study are flagged and followed-up via the Scottish Cancer Registry.Results: 9.77% of those tested have had a positive blood test with 17 lung cancers and 2 CT abnormalities currently undergoing further investigation in those who tested positive. Fifteen of the 16 cancers have been staged and 12 of these are early cancers.Conclusion: At this point there seems a higher rate of early stage diagnosis than in clinical practice. ER -