RT Journal Article
SR Electronic
T1 Traffic-related air pollution exposure over a 5-year period is associated with increased risk of asthma and poor lung function in middle age
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1602357
DO 10.1183/13993003.02357-2016
VO 50
IS 4
A1 Gayan Bowatte
A1 Bircan Erbas
A1 Caroline J. Lodge
A1 Luke D. Knibbs
A1 Lyle C. Gurrin
A1 Guy B. Marks
A1 Paul S. Thomas
A1 David P. Johns
A1 Graham G. Giles
A1 Jennie Hui
A1 Martine Dennekamp
A1 Jennifer L. Perret
A1 Michael J. Abramson
A1 E. Haydn Walters
A1 Melanie C. Matheson
A1 Shyamali C. Dharmage
YR 2017
UL http://erj.ersjournals.com/content/50/4/1602357.abstract
AB Current evidence concerning the impact of exposure to traffic-related air pollution (TRAP) on adult respiratory morbidity mainly comes from cross-sectional studies. We sought to establish more robust measures of this association and potential gene–environment interactions using longitudinal data from an established cohort study.Associations between measures of TRAP (nitrogen dioxide (NO2) and distance to major roads) and wheeze, asthma prevalence and lung function were investigated in participants of the Tasmanian Longitudinal Health Study at 45- and 50-year follow-ups. Generalised estimating equations were used to quantify associations and the potential modifying effect of glutathione S-transferase gene variants.Living <200 m from a major road was associated with increased prevalence of current asthma and wheeze, and lower lung function. The association between living <200 m from a major road and current asthma and wheeze was more marked for carriers of the GSTT1 null and GSTP1 val/val or ile/val genotypes. Over the 5-year period, higher NO2 exposures were associated with increased current asthma prevalence. Higher NO2 exposure was associated with lower forced vital capacity for carriers of the GSTT1 null genotype.TRAP exposures were associated with increased risk of asthma, wheeze and lower lung function in middle-aged adults. The interaction with the GSTT1 genotype suggests that deficient antioxidant mechanisms may play a role in these adverse health effects.TRAP is associated with increased risks of asthma and reduced lung function in middle-aged adults http://ow.ly/Yt2n30etMkS