RT Journal Article
SR Electronic
T1 A longitudinal modelling study estimates acute symptoms of community acquired pneumonia recover to baseline by 10 days
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1602170
DO 10.1183/13993003.02170-2016
VO 49
IS 6
A1 Daniel G. Wootton
A1 Laura Dickinson
A1 Henry Pertinez
A1 Joanne Court
A1 Odiri Eneje
A1 Lynne Keogan
A1 Laura Macfarlane
A1 Sarah Wilks
A1 Jane Gallagher
A1 Mark Woodhead
A1 Stephen B. Gordon
A1 Peter J. Diggle
YR 2017
UL http://erj.ersjournals.com/content/49/6/1602170.abstract
AB Our aims were to address three fundamental questions relating to the symptoms of community-acquired pneumonia (CAP): Do patients completely recover from pneumonia symptoms? How long does this recovery take? Which factors influence symptomatic recovery?We prospectively recruited patients at two hospitals in Liverpool, UK, into a longitudinal, observational cohort study and modelled symptom recovery from CAP. We excluded patients with cancer, immunosuppression or advanced dementia, and those who were intubated or palliated from admission. We derived a statistical model to describe symptom patterns.We recruited 169 (52% male) adults. Multivariable analysis demonstrated that the time taken to recover to baseline was determined by the initial severity of symptoms. Severity of symptoms was associated with comorbidity and was inversely related to age. The pattern of symptom recovery was exponential and most patients’ symptoms returned to baseline by 10 days.These results will inform the advice given to patients regarding the resolution of their symptoms. The recovery model described here will facilitate the use of symptom recovery as an outcome measure in future clinical trials.Severity of CAP symptoms is inversely related to age and resolution to baseline symptoms takes on average 10 days http://ow.ly/dV0h30befE3