RT Journal Article
SR Electronic
T1 Volatolomics of breath as an emerging frontier in pulmonary arterial hypertension
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1601897
DO 10.1183/13993003.01897-2016
VO 49
IS 2
A1 Morad K. Nakhleh
A1 Hossam Haick
A1 Marc Humbert
A1 Sylvia Cohen-Kaminsky
YR 2017
UL http://erj.ersjournals.com/content/49/2/1601897.abstract
AB There is accumulating evidence in support of the significant improvement in survival rates and clinical outcomes when pulmonary arterial hypertension (PAH) is diagnosed at early stages. Nevertheless, it remains a major clinical challenge and the outcomes are dependent on invasive right heart catheterisation.Resulting from pathophysiological processes and detectable in exhaled breath, volatile organic compounds (VOCs) have been proposed as noninvasive biomarkers for PAH. Studies have confirmed significant alterations of the exhaled VOCs among PAH patients when compared to controls and/or patients with other respiratory diseases. This suggests exhaled breath analysis as a potential noninvasive medical application in the field of PAH.In this article, we review and discuss the progress made so far in the field of exhaled volatolomics (the omics of VOCs) as a potential noninvasive diagnostics of PAH. In addition, we propose a model including possible biochemical pathways on the level of the remodelled artery, in which specific VOCs could be detectable in exhaled breath during the early phases of PAH. We debate the different analytical approaches used and recommend a diagram including a “bottom–top” strategy, from basic to translational studies, required for promoting the field.Volatile organic compounds: exhaled volatolomics analysis for noninvasive early diagnosis of PAH http://ow.ly/4R6Q306A0zJ