TY - JOUR T1 - Urinary prostanoids in preschool wheeze JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01390-2016 VL - 49 IS - 2 SP - 1601390 AU - Jonathan Grigg AU - Abigail Whitehouse AU - Hitesh Pandya AU - Stephen Turner AU - Christopher J. Griffiths AU - Tom Vulliamy AU - Robert T. Walton AU - David B. Price AU - Marek Sanak AU - John W. Holloway AU - Lee Noimark AU - Maia Lesosky AU - Rossa Brugha AU - Lee Koh AU - Chinedu Nwokoro Y1 - 2017/02/01 UR - http://erj.ersjournals.com/content/49/2/1601390.abstract N2 - Acute episodes of wheeze in children of preschool age are frequently triggered by viral upper respiratory tract infections and result in a significant burden to health services [1]. However, to date, the inflammatory mechanisms underlying preschool wheeze remain unclear. Mediators that have not been studied in preschool wheeze, but are implicated in the pathogenesis of wheeze in adults with asthma, include the pro-inflammatory prostanoid prostaglandin D2 (PGD2) [2] and the anti-inflammatory prostanoid PGE2 [3, 4]. In this study, we sought evidence for either increased PGD2 biosynthesis or reduced PGE2 biosynthesis, or a combination of both in children with preschool wheeze. To achieve this, we measured the major metabolites of PGD2 and PGE2 in the urine: 9α-hydroxy-11,15-dioxo-2,3,4,5-tetranor-prostan-1,20-dioic acid (tetranor-PGDM) and 9,15-dioxo-11α-hydroxy-13,14-dihydro-2,3,4,5-tetranor-prostan-1,20-dioic acid (tetranor-PGEM), respectively [5, 6].Tetranor PGDM, a urinary metabolite of prostaglandin D2, is increased in children with preschool wheeze http://ow.ly/Ynjy305ZY9LThe author contributions are as follows. J. Grigg was the chief investigator, planned and provided overall supervision of the study, wrote the manuscript and vouches for these data. A. Whitehouse performed data analysis and contributed to the final manuscript. M. Lesosky undertook the multiple regression analysis and contributed to the final manuscript. C. Nwokoro and R. Brugha supervised the study and contributed to the final manuscript. H. Pandya, S. Turner, R. Walton and D. Price contributed to study planning and to drafting the final manuscript. T. Vulliamy, J.W. Holloway and C.J. Griffiths contributed to study planning and contributed to the final manuscript. M. Sanak performed urinary prostanoid analysis and contributed to the final manuscript. L. Noimark obtained data from controls and contributed to the final manuscript. L. Koh supervised data from controls, collated data and contributed to the final manuscript. ER -