PT  - JOURNAL ARTICLE
AU  - Meriem Benmerad
AU  - Rémy Slama
AU  - Karine Botturi
AU  - Johanna Claustre
AU  - Antoine Roux
AU  - Edouard Sage
AU  - Martine Reynaud-Gaubert
AU  - Carine Gomez
AU  - Romain Kessler
AU  - Olivier Brugière
AU  - Jean-François Mornex
AU  - Sacha Mussot
AU  - Marcel Dahan
AU  - Véronique Boussaud
AU  - Isabelle Danner-Boucher
AU  - Claire Dromer
AU  - Christiane Knoop
AU  - Annick Auffray
AU  - Johanna Lepeule
AU  - Laure Malherbe
AU  - Frederik Meleux
AU  - Laurent Nicod
AU  - Antoine Magnan
AU  - Christophe Pison
AU  - Valérie Siroux
TI  - Chronic effects of air pollution on lung function after lung transplantation in the Systems prediction of Chronic Lung Allograft Dysfunction (SysCLAD) study
AID  - 10.1183/13993003.00206-2016
DP  - 2017 Jan 01
TA  - European Respiratory Journal
PG  - 1600206
VI  - 49
IP  - 1
4099  - http://erj.ersjournals.com/content/49/1/1600206.short
4100  - http://erj.ersjournals.com/content/49/1/1600206.full
SO  - Eur Respir J2017 Jan 01; 49
AB  - An irreversible loss in lung function limits the long-term success in lung transplantation. We evaluated the role of chronic exposure to ambient air pollution on lung function levels in lung transplant recipients (LTRs).The lung function of 520 LTRs from the Cohort in Lung Transplantation (COLT) study was measured every 6 months. The levels of air pollutants (nitrogen dioxide (NO2), particulate matter with an aerodynamic cut-off diameter of x µm (PMx) and ozone (O3)) at the patients' home address were averaged in the 12 months before each spirometry test. The effects of air pollutants on forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) in % predicted were estimated using mixed linear regressions. We assessed the effect modification of macrolide antibiotics in this relationship.Increased 12-month levels of pollutants were associated with lower levels of FVC % pred (−2.56%, 95% CI −3.86–−1.25 for 5 µg·m−3 of PM10; −0.75%, 95% CI −1.38–−0.12 for 2 µg·m−3 of PM2.5 and −2.58%, 95% CI −4.63–−0.53 for 10 µg·m−3 of NO2). In patients not taking macrolides, the deleterious association between PM and FVC tended to be stronger and PM10 was associated with lower FEV1.Our study suggests a deleterious effect of chronic exposure to air pollutants on lung function levels in LTRs, which might be modified with macrolides.Chronic exposure to air pollutants is associated with reduced lung function in lung transplant recipients http://ow.ly/gH8e304Qac4