TY - JOUR T1 - Correlation between matrix metalloproteinase-9 serum levels and disease severity in pulmonary tuberculosis patients JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2016.PA2723 VL - 48 IS - suppl 60 SP - PA2723 AU - Eliana Muis AU - Erwin Arief AU - Irawaty Djaharuddin Y1 - 2016/09/01 UR - http://erj.ersjournals.com/content/48/suppl_60/PA2723.abstract N2 - Background: The matrix metalloproteinase-9 (MMP-9), which induced by lipoarabinomannan in Mycobacterium tuberculosis, is capable to degrade type IV collagen, the main component of basement membrane in lung. Several study of PTB found that serum level of MMP-9 was high, and correlated with radiographic finding.Objectives: To evaluate the correlation between serum level of MMP-9 and disease severity in PTB patients.Methods: A cross sectional study was conducted from February until October 2011. Subjects were new cases of positive smear PTB, age ≥15 years, in Dr. Wahidin Sudirohusodo Hospital Makassar. All subjects were evaluated for serum level of MMP-9 and chest x-ray to determine disease severity of PTB.Results: Total of 66 subjects were collected, aged between 16-70 years, consisted of 41 males (62.1%) and 25 women (37.9%). The lowest serum level of MMP-9 was 123.4 ng/ml, the highest 2000 ng/ml (mean 1038±580.4 ng/ml). Mean serum level of MMP-9 was higher in women (1205.7 ng/ml) than men (937.1 ng/ml), and underweight (1074.8 ng/ml) than obese plus normal BMI category (990.1 ng/ml). Mean serum level of MMP-9 in extensive lesion (1379.9 ng/ml) was significantly higher than moderate lesions (717.9 ng/ml; p<0.001).Conclusion: There is a correlation between serum level of MMP-9 with disease severity in PTB patients. Mean serum level of MMP-9 is higher in extensive lesions, female and underweight. Also, there is a tendency that the older the age, the lower the serum level of MMP-9. ER -