RT Journal Article
SR Electronic
T1 Clinical Impact of Gensini score in chronic obstructive pulmonary disease (COPD)
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA4160
DO 10.1183/13993003.congress-2016.PA4160
VO 48
IS suppl 60
A1 Joo Hun Park
A1 Keu Sung Lee
A1 Wou Young Chung
A1 Seungsoo Sheen
A1 Jung Yeon Lee
A1 Hong-Seok Lim
A1 Joon-Han Shin
A1 Seung-Jea Tahk
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA4160.abstract
AB Background: In COPD, coronary artery disease (CAD) is a frequent co-morbidity and cardiovascular disease is the most common cause of death. When coronary angiography was performed, the Gensini score is used for the assessment of CAD severity. This study was performed to evaluate the clinical impact of Gensini score in COPD.Methods: We retrospectively reviewed 191 patients with COPD (male 90.1%, mean age 68.5 ± 8.9 years, smoker 86.2%) who had undergone coronary angiography in Ajou University Hospital from Jan 2000 to Dec 2012. The extent of CAD in the entire coronary arterial tree was assessed by Gensini score. Comparative analyses between high Gensini group (≥4 points; median value or more) and low Gensini group (<4 points) were performed.Results: High Gensini group was more frequently associated with triple vessel CAD (37.2% vs. 1.0%, p<0.001), myocardial infarction (37.2% vs. 8.2%, p<0.001), and cerebrovascular stroke (8.6% vs. 2.1%, p<0.045) than low gensini group. High Gensini group had lower left ventricular ejection fraction (57.9 ± 13.6 vs. 62.1 ± 12.2%, p=0.027), but FEV1(66.4 ± 16.9 vs 64. 9 ± 19.0, p=0.583) and prevalence of hypertension (59.6% vs. 57.7%, p=0.796) did not differ between two groups. High Gensini group was independently related to triple vessel CAD (OR 3.51, 95% CI 1.77 – 6.94) and myocardial infarction (OR 5.38, 95% CI 1.83 – 15.82).Conclusion: Our data suggest that high Gensini score in COPD was independently associated with cardiac co-morbidities such as triple vessel CAD and myocardial infarction.