RT Journal Article
SR Electronic
T1 Characteristics of HIV-positive and HIV-negative new tuberculosis cases in Moscow, Russia
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA2766
DO 10.1183/13993003.congress-2016.PA2766
VO 48
IS suppl 60
A1 Michael Sinitsin
A1 Evgeny Belilovskiy
A1 Sergey Borisov
A1 Evgenia Kotova
A1 Ludmila Rybka
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA2766.abstract
AB Background: Growth of prevalence HIV is the one of the challenges of TB control in Moscow. Effectiveness of diagnostics and treatment activities with TB-HIV cases strongly depend on knowledge about particularities of HIV-positive TB patients.Methods: New TB cases among residents registered in 2013-2014 in Moscow city were analyzed including 1076 HIV-positive (TB-HIVp) and 5531 HIV-negative patients (TB-HIVn). Data of the resident status, age, gender and TB localizations were evaluated.Results: There were 43% and 27.2% of not residents (NRS) among TB-HIVp and TB-HIVn, accordingly.Proportion of men was more among TB-HIVp than among TB-HIVn for residents (RS): 67.8% vs. 60.5%, OR=1.4 (95% CI 1.2-1.6). Patients in 31-40 age registered more often for TB-HIVp than for TB-HIVn, both for RS (65.3% vs. 21.0%, OR=7.1, 95% CI 6.0-8.4) and for NRS (OR=3.0, 2.3-3.8), accordingly.TB-HIVp were mostly unemployed persons: OR=4.9 (4.1-5.8) and 2.7 (2.0-3.7) for RS and NRS, and ex-prisoners (for RS): OR=5.1 (2.4-3.5).The one third of TB-HIVp (37.7%, 38.4-53.2) had few localizations of disease; 56.3% (51.5-60.9) of TB-HIVp had at least one extra-pulmonary TB localization (EPTB), including TB of introthoraciclymph nodes: 34.2% (29.8-38.7) and abdominal TB: 17.6% (14.2-21.4). TB-HIVn had only 10.8% (9.8-12.0) of EPTB.The half of both groups patients were bacteriological positive (MBT+): 50.8% and 49.8%, p>0.05 (for RS), but the MBT+ EPTB cases were more often among TB-HIVp: OR= 3.9 (2.7 – 5.7). MDR TB among patients with DST results was higher for TB-HIVp than for TB-HIVn: 18% and 13.2%, but with p>0.05.Conclusions: Target activities in TB control need taking into account the value of HIV impact on TB epidemiology.