RT Journal Article SR Electronic T1 Is the sit-to-stand test (STST) a valuable tool for the evaluation of the impact of a pulmonary rehabilitation program (PRP) in COPD? Results from the French cohort rehaeffort from IRSR des Pays de Loire JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP PA1569 DO 10.1183/13993003.congress-2016.PA1569 VO 48 IS suppl 60 A1 Arnaud Chambellan A1 Trija Vaidya A1 Claire de Bisschop A1 Hakima Ouksel A1 Laurence Nourry A1 Anne Vincent YR 2016 UL http://erj.ersjournals.com/content/48/suppl_60/PA1569.abstract AB The STST1 could be valuable to assess the level of exercise tolerance in COPD. There is a need to clarify 1) if a familiarization test is required, 2) the reliability of the test, and 3) the responsiveness to a PRP in terms of a minimal important difference (MID).32 COPD patients and 14 healthy individuals were included. The STST1 was performed twice at 15 minutes interval and repeated after 48 hours. A complete evaluation was obtained at the inclusion and the end of the PRP as recommended. Responsiveness to PR was determined by the difference in the STST1 from the inclusion to the end of PRP.In the COPD group (64.1 ± 10.4 years; FEV1 of 53.2 ± 16% predicted) and the healthy group (59.4 ± 6.1 years), there was a tendency for a familiarization effect from 16.5 ± 4.0 to 17.4 ± 4.4 (p=0.138) in COPD, and from 37.0 ± 8.4 to 39.1.3 ± 9.2 (p=0.097) in the healthy group respectively. The STST1 showed excellent test-retest reliability in both groups with the ICC of 0.903 (95CI: 0.697 to 0.969) in COPD and 0.977 (95CI: 0.925 to 0.993) in the healthy group. The STST1 was correlated with the 6MWD (r = 0.649, p<10-4). In the COPD group, the number of STS rose from 18.1 ± 5.5 to 22.4 ± 7.6 (p=0.001). Using the distribution-based method, the MID was 3. With the 6MWD and the quadriceps strength as anchored, it was between 2 and 7 (AUC 0.704) and 2.5 and 3.5 (AUC 0.857) respectively.The STST1 is a simple and reliable field test sensitive to measure the effect of a pulmonary rehabilitation program. Based on these result, we suggest to set the MID at 3.