TY - JOUR T1 - Effects of a 6 week whole-body vibration training (WBVT) in stable COPD patients: A randomized clinical trial JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2016.PA2216 VL - 48 IS - suppl 60 SP - PA2216 AU - Maite Jiménez Siebert AU - Tobias Boeselt AU - Timm Greulich AU - Peter Alter AU - Felix Herth AU - Nicolas Kahn AU - Florian Bornitz AU - Claus Vogelmeier AU - Christoph Nell AU - Simone Hummler AU - Andreas Rembert Koczulla Y1 - 2016/09/01 UR - http://erj.ersjournals.com/content/48/suppl_60/PA2216.abstract N2 - Introduction: Abstention from exercise results in reduced mobility, loss of cardiopulmonary capacity and social isolation.Aims and objectives: WBVT has been proven as a safe training method which produces benefits regarding exercise capacity, dyspnoea and health-related quality of life (Greulich, T., et al. BMC Pulm Med, 2014. 14: p. 60). We aimed to evaluate whether WBVT has an impact on lung function, physical capacity and diaphragmatic movement and strength.Methods: Between May and Dec 2015, 22 stable patients I-IV (FEV1 (SG) 51.9 ± 22% (TG) 57.1 ± 20.8%) were randomized (1:1) to receive sham (SG) training at 5 Hz or WBVT (TG) (starting with 14Hz up to 28 Hz). Physical endurance (6 Minute Walk Test, Chair Rising Test), lung function and diaphragmatic parameters (P0.1, PImax, diaphragm ultrasound), quality of life (SF-12, PHQ-9) and symptoms (SGRQ, CAT, mMRC) were measured at the time of enrolment (T0), after completing the training period (T1) and 6 weeks after having completed the training (T2).Results: Our preliminary data analysis showed an improvement (1.68 ± 2.34mm; p<0,05) of diaphragm muscle thickness after the training period (TG= T0: 6.3 ± 1.8; T1: 7.6 ± 1.3; T2: 5.5 ± 1.3mm/SG= T0: 5.1 ± 0.8; T1: 6.15 ± 1.9; T2: 6.1 ± 2.6mm). 6 weeks later, a decrease of thickness was found (-1.9 ± 2.2mm; p<0.05). We saw no significant differences between both groups in the functional respiratory measurements, especially PImax.Conclusion: The first results after TG-WBVT showed promising effects in diaphragm muscle increase. No change in diaphragm strength was found which might be due to the short training episode. Further recruitment up to 40 patients will be done. ER -