RT Journal Article
SR Electronic
T1 Can procalcitonin or C-reactive protein predict supporative lung complications and ARDS at severe community-acquired pneumonia (CAP)?
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA600
DO 10.1183/13993003.congress-2016.PA600
VO 48
IS suppl 60
A1 Kseniia Bielosludtseva
A1 Tetyana Pertseva
A1 Tetyana Kireyeva
A1 Nataliia Sanina
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA600.abstract
AB Objectives: to determine the significance of markers procalcitonin (PCT) and C-reactive protein (CRP) as predictors of different pulmonary complications in patients with severe CAP.Methods: main group – 60 patients with verified severe CAP without HIV (age – from 18 to 78 years, men – 41 (68,3%)). General analysis, determination of serum PCT and CRP prior antibacterial treatment (ABT) (visit 1), on 8–10 day of ABT (visit 2), statistic. Control group – 10 healthy people.Results: are present in table nserum PCT, ng/ml visit 1serum PCT, ng/ml visit 2serum CRP, mg/lserum CRP, mg/lmain group5116,8±3,2∧0,08±0,02274,3±18,7250,5±7,4Died1023,7±6,4∧28,5±12,6∗309,3±38,9∧432,1±68,3Supporative pulmonary complications2321,5±11,4∗∧0,12±0,03323,5±32,6∧75,5±9,4ARDS1114,8±6,815,0±5,9∗228,5±33,9235,6±28,6∗Control group100,021±0,01∗0,021±0,01∗4,03±0,11∗4,03±0,11Notes: ∗ - p<0,05 compared with main group by Mann-Whitney, ∧ - p< 0,05 between visit1-visit2 by WilcoxonInitial and dynamic level of inflammatory markers in patients with severe CAPConclusions: Only PCT but not CRP may be predictor of lung complications at severe CAP:· Patients with Initial level of PCT higher than 15 ng/ml have risk of supporative lung inflammatory complications (abscess, empyema, pneumothorax)· Only dynamic increasing of PCT may be predictor of mortality· Neither initial no dynamic level of PCT can predict ARDS.