RT Journal Article
SR Electronic
T1 LATE-BREAKING ABSTRACT: Poor outcome following lung transplantation in CF patients infected with mycobacterium abscessus appears to be associated with two genetic clusters of mycobacterium abscessus subspecies abscessus
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA4872
DO 10.1183/13993003.congress-2016.PA4872
VO 48
IS suppl 60
A1 Ema Kavaliunaite
A1 Kathryn A. Harris
A1 Paul Aurora
A1 Garth Dixon
A1 Delane Shingadia
A1 Nagarajan Muthialu
A1 Helen Spencer
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA4872.abstract
AB Mycobacterium abscessus is associated with poor outcome following lung transplantation. We investigated whether outcome was related to subspecies and genetic cluster. CF patients transplanted at GOSH from 2004 – 2016 were retrospectively examined. Medical notes, microbiology, radiology databases and operative notes were reviewed. All M. abscessus isolates identified to subspecies level by PCR sequencing and genetic cluster determined by variable number tandem repeat (VNTR) profiling and whole genome sequencing. 11 patients with chronic M. abscessus infection (AAFB smear positive) underwent bilateral lung transplantation. Outcomes are shown in table. Dramatically worse outcomes were seen in patients infected with M. abscessus subspecies abscessus, genetic clusters VNTR I and II, compared with other strains. We have reported for the first time an association between lung transplant outcome in CF patients and M. abscessus genetic cluster and advise great caution in transplanting patients infected with genetic clusters VNTR I or II. However, patients infected with other M. abscessus strains appear to have acceptable outcomes.NoAge at Lung TxM. abscessus subspeciesGenetic clusterOutcome110.8bolletiiUniqueWell214.5massilienseUniqueWell310.0massilienseUniqueWell411.11massilienseVNTR IIIWell514.1abscessusUniqueWell616.2abscessusVNTR IDied 4y post LTx717.2abscessusVNTR IIDied 1.7y post LTx89.2abscessusVNTR IIOn-going treatment915.1abscessusVNTR IIDied 25d post LTx1014.4abscessusVNTR IDied 2m post LTx1115.1abscessusVNTR IDied 2m post LTx