TY - JOUR T1 - Predictive factors for the development of fixed airway obstruction in asthmatic children and adolescents JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2016.PA3347 VL - 48 IS - suppl 60 SP - PA3347 AU - Andrey Sousa AU - Anna Cabral AU - Milton Martins AU - Celso Carvalho Y1 - 2016/09/01 UR - http://erj.ersjournals.com/content/48/suppl_60/PA3347.abstract N2 - Background: Asthma is a disease with reversible bronchoconstriction, but some patients develop fixed airway obstruction (FAO); however, the factors leading to FAO remains poorly known.Objective: To identify predictive factors related to the development of FAO in children and adolescents in treatment for asthma.Method: This observational study included 362 consecutive asthmatic children and adolescents of both genders, aged 7 to 20 years old, from January 2012 through December 2015. After receiving the medical diagnosis, all patients received optimized pharmacological treatment for a minimum of 12 months in accordance with the Global Initiative for Asthma guidelines. During the treatment period, a minimum of 4 pulmonary function tests were performed to detect the existence of FAO (FEV1 /FVC < the lower limit of predicted normal).Results: In 32 of the patients studied (8.8%) FAO was detected. A history of frequent exacerbations (Odds Ratio [OR] of 3.9 and a 95% Confidence Interval [CI] of 1.3-11.7) and severe asthma ([OR] of 3.5 and a 95% [CI] of 1.6-7.6) were the variables that determined the presence of FAO.Conclusion: A history of frequent exacerbations and severe asthma were determining factors for the appearance of FAO in our population asthmatic children and adolescents. Prevention of asthma attacks can help improve lung function. ER -