RT Journal Article SR Electronic T1 LATE-BREAKING ABSTRACT: Risk factors for hospitalization and death in elderly smokers with chronic obstructive pulmonary disease (COPD) and/or chronic heart failure (CHF) JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP PA3712 DO 10.1183/13993003.congress-2016.PA3712 VO 48 IS suppl 60 A1 Alessia Verduri A1 Bianca Beghé A1 Martina Garofalo A1 Sara Balduzzi A1 Michela Schito A1 Valentina Ruggieri A1 Alessandro Fucili A1 Leonardo M. Fabbri A1 Enrico Clini A1 Piera Boschetto YR 2016 UL http://erj.ersjournals.com/content/48/suppl_60/PA3712.abstract AB Aim: We examined 2 groups of elderly (≥65yrs) smokers (≥20p/y) with primary diagnosis of COPD and/or CHF to investigate prospectively the risk factors for hospitalization and death due to cardiopulmonary events over 3 yrs.Methods: In 144 COPD pts (68-77 yrs;male 76%) and 96 CHF pts (71-78 yrs;male 91%), we assessed age-adjusted Charlson Index (CCI), COPD Assessment Test (CAT), modified Medical Research Council (mMRC) dyspnea scale, spirometry, and echocardiography.Results: COPD pts were in GOLD classes I(32), II(79), III(30), IV(3), whereas CHF in NYHA classes I(40), II(49), III(6), missing in 1 patient. Among CHF pts, 26% had airflow limitation (mostly with moderate obstructive ventilatory pattern). The prevalence of CHF in COPD pts was 5% (mainly NYHA class I). CCI score was greater in CHF as compared to COPD pts (p<0.001). CAT score was higher in COPD vs CHF pts (p<0.001.) The major risk factors for hospitalization were age ≥80yrs [odds ratio (OR) and 95% confidence interval (CI) 3.02 (1.28 to 7.12)], greater CCI [OR(CI) 1.38 (1.16 to 1.63)], lower lung function (FEV1post-BD) [OR(CI) 0.98 (0.97 to 0.99)], and higher mMRC grade [OR(CI) 1.38 (1.16 to 1.63)]. Moreover, age ≥80yrs [OR(CI) 5.98 (1.73 to 20.7)], greater CCI [1.41 (1.16 to 1.71)] and higher mMRC grade [1.79 (1.22 to 2.64)] were the most important risk factors for death.Conclusions: Older age, comorbidities and dyspnea are major risk factors for hospitalization and death due to cardiopulmonary causes in smokers with COPD and/or CHF. Lower lung function predicts only the future risk of hospital admission in these patients.Funded by Ministry of Health, CFR, Chiesi Foundation: