%0 Journal Article %A Alessia Verduri %A Bianca Beghé %A Martina Garofalo %A Sara Balduzzi %A Michela Schito %A Valentina Ruggieri %A Alessandro Fucili %A Leonardo M. Fabbri %A Enrico Clini %A Piera Boschetto %T LATE-BREAKING ABSTRACT: Risk factors for hospitalization and death in elderly smokers with chronic obstructive pulmonary disease (COPD) and/or chronic heart failure (CHF) %D 2016 %R 10.1183/13993003.congress-2016.PA3712 %J European Respiratory Journal %P PA3712 %V 48 %N suppl 60 %X Aim: We examined 2 groups of elderly (≥65yrs) smokers (≥20p/y) with primary diagnosis of COPD and/or CHF to investigate prospectively the risk factors for hospitalization and death due to cardiopulmonary events over 3 yrs.Methods: In 144 COPD pts (68-77 yrs;male 76%) and 96 CHF pts (71-78 yrs;male 91%), we assessed age-adjusted Charlson Index (CCI), COPD Assessment Test (CAT), modified Medical Research Council (mMRC) dyspnea scale, spirometry, and echocardiography.Results: COPD pts were in GOLD classes I(32), II(79), III(30), IV(3), whereas CHF in NYHA classes I(40), II(49), III(6), missing in 1 patient. Among CHF pts, 26% had airflow limitation (mostly with moderate obstructive ventilatory pattern). The prevalence of CHF in COPD pts was 5% (mainly NYHA class I). CCI score was greater in CHF as compared to COPD pts (p<0.001). CAT score was higher in COPD vs CHF pts (p<0.001.) The major risk factors for hospitalization were age ≥80yrs [odds ratio (OR) and 95% confidence interval (CI) 3.02 (1.28 to 7.12)], greater CCI [OR(CI) 1.38 (1.16 to 1.63)], lower lung function (FEV1post-BD) [OR(CI) 0.98 (0.97 to 0.99)], and higher mMRC grade [OR(CI) 1.38 (1.16 to 1.63)]. Moreover, age ≥80yrs [OR(CI) 5.98 (1.73 to 20.7)], greater CCI [1.41 (1.16 to 1.71)] and higher mMRC grade [1.79 (1.22 to 2.64)] were the most important risk factors for death.Conclusions: Older age, comorbidities and dyspnea are major risk factors for hospitalization and death due to cardiopulmonary causes in smokers with COPD and/or CHF. Lower lung function predicts only the future risk of hospital admission in these patients.Funded by Ministry of Health, CFR, Chiesi Foundation: %U