RT Journal Article SR Electronic T1 Clinical characteristics and outcomes of pulmonary tuberculosis in patients with diabetes mellitus JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP PA2659 DO 10.1183/13993003.congress-2016.PA2659 VO 48 IS suppl 60 A1 Abir Hedhli A1 Hajer Racil A1 Sonia Habibech A1 Saoussen Bacha A1 Sana Cheikhrouhou A1 Naouel Chaouch A1 Abdellatif Chabbou YR 2016 UL http://erj.ersjournals.com/content/48/suppl_60/PA2659.abstract AB Introduction: The association of pulmonary tuberculosis and diabetes presents clinical, radiological and therapeutic particularities.Objectives: To determine the clinical and radiological characteristic and outcomes of pulmonary tuberculosis (PT) in patients with diabetes mellitus.Materials and Methods: we conducted a retrospective case-control study between 2007 and 2012 on 120 patients hospitalized in a pulmonology department for a first episode of confirmed PT. patients were divided into two groups: group 1 (G1) represents 30 diabetics and Group 2 (G2) included 90 non diabetic patients.Results: The mean age was 45.5 years in G1 and was comparable to the G2. All patients were male. Diabetes was type 2 in 76% of cases. General symptoms were more frequent in the G2 (p=0.04). Dyspnea was more noted in the G1 (p=0.03). The classical various types of radiological lesions of PT were found in similar proportion in the two groups with parenchymal shadowing the most frequent appearance in both diabetics (86%) and control (84%). However cavitations occurred less frequently in diabetics than controls (p=0,04). Radiological abnormalities were bilateral and diffuse in 65% of cases of G1 against 45% in G2 (p=0.01). There was a trend for basal lesions to occur more frequently in diabetics than controls (p=0.005). The delay of sputum smear conversion was longer in G1(p=0.03). An extension of the duration of treatment was necessary in 22% of patients in the G2. Two patients died in the G1 within the first 24 hours of hospitalization.Conclusion: Diabetics have severe forms of tuberculosis, atypical and often extensive radiographic abnormalities, requiring special care to prevent complications.