TY - JOUR T1 - Risk of cardiovascular comorbidities in patients with idiopathic pulmonary fibrosis: Analysis of Medicare data JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2016.PA4919 VL - 48 IS - suppl 60 SP - PA4919 AU - Michael Broder AU - Eunice Change AU - Elya Papoyan AU - Iona Popescu AU - Sheila Reddy AU - Karina Raimundo AU - Will Chou AU - John Stauffer Y1 - 2016/09/01 UR - http://erj.ersjournals.com/content/48/suppl_60/PA4919.abstract N2 - Introduction: Idiopathic pulmonary fibrosis (IPF) is associated with an increased risk of cardiovascular (CV) comorbidities. Little is known about this relationship in the Medicare population.Objective: To determine the risk of CV comorbidities of Medicare patients (pts) with IPF.Methods: Using Medicare data we examined characteristics of senior pts in the US who were newly diagnosed with IPF in 2010 (ICD-9: 516.3) and who lacked indication of a non-IPF ILD after the last observed IPF claim compared with IPF disease-free pts. IPF pts were matched and compared to IPF-free controls (1:1 per age, gender, and region) from 5% sample data set. Medicare plan enrollment was constant the year before diagnosis (baseline). Baseline demographics and comorbidities were compared between groups. Absolute risk difference (RD) is reported.Results: We identified 13,615 IPF pts and their matched controls. Mean age (SD) in the groups was 78.9 years (7.1), 50.3% were male. Compared to controls, IPF pts had higher mean [SD] number of chronic conditions (6.3 [2.2] vs 4.7 [2.4]; P<.001) and Charlson Comorbidity Index (3.6 [2.9] vs 2.3 [2.7]; P<.001). Rates of CV comorbidities were consistently higher in IPF pts: CV conditions (RD: 23.4%), ischemic heart disease (RD: 17.6%), congestive heart failure (RD: 19.8%), pulmonary hypertension (RD: 5.6%), atrial fibrillation (RD: 8.7%), venous thromboembolism (RD: 4.7%), and stroke (RD: 0.9%)(all P<.005).Conclusions: Newly diagnosed IPF pts are typically sicker than non-IPF pts and have significantly higher rates of CV conditions. The higher rate of CV conditions needs to be taken into consideration for the management and treatment of pts with IPF. ER -