RT Journal Article
SR Electronic
T1 COPD and lung cancer: Prevalence, infradiagnosis, phenotypes and multidimensional characterization
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA2792
DO 10.1183/13993003.congress-2016.PA2792
VO 48
IS suppl 60
A1 Virginia Leiro-Fernandez
A1 Isaura Parente-Lamelas
A1 Cristina Represas-Represas
A1 Jose Abal- Arca
A1 Esmeralda García-Rodriguez
A1 Ana Priegue-Carrera
A1 Cristina Ramos-Hernández
A1 Cecilia Mouronte-Roibás
A1 Maribel Botana-Rial
A1 Alberto Fernández-Villar
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA2792.abstract
AB INTRODUCTION AND OBJECTIVES: Although there is an association between Lung Cancer (LC) and COPD (Chronic Obstructive Pulmonary Disease) there are few data about the grade of coexistence, COPD infradiagnosis, phenotypes and multidimensional parameters. The aims of this study were to determine these issues.METHODOLOGY: Prospective observational multicenter study divided in two substudies. Substudy 1 is descriptive and analyzed patients with LC and COPD concomitant. Subestudy 2 is a case-control comparative in which cases are LC with concomitant COPD (LC-COPD) individuals and controls COPD with no evidence of LC.RESULTS: From January 2014-July 2015 were included 498 LC, 78.7% male, age 68 (10). COPD was diagnosed in 214 (43%) being the underdiagnosis of 67.8%. After multivariate analysis, LC-COPD were older [OR: 1.06; 95%CI (1.03-1.1), p<0.001], active smokers [OR: 2.43; 95%CI (1.34-4.4), p= 0.003], higher rates years/package [OR 1.01 95%CI (1-1.02), p=0.03] and Squamous type [OR: 2.08 95%CI (1.16-3.89), p=0.02]. LC-COPD patients were compared with 138 COPD controls. After multivariate analysis patients with LC-COPD had fewer exacerbations in the last year [OR 0.6 95%CI (0.43-0.9), p=0.01], lower DLCO% [OR: 0.96 95%CI (0.95-0.98), p=0.001] and greater comorbidity (Charlson Index) [OR: 1.47 95%CI (1.21-1.7, p<0.001)].CONCLUSION: The prevalence of COPD in patients with LC is 43% and there is high level of underdiagnosis (67.8%).LC-COPD patients are more frequently scamous type and related to smoking and aging. COPD patients with increased morbidity, less exacerbations and lower DLCO values could be a higher risk group of LC.Study founded by Menarini group.