%0 Journal Article %A Virginia Leiro-Fernandez %A Isaura Parente-Lamelas %A Cristina Represas-Represas %A Jose Abal- Arca %A Esmeralda García-Rodriguez %A Ana Priegue-Carrera %A Cristina Ramos-Hernández %A Cecilia Mouronte-Roibás %A Maribel Botana-Rial %A Alberto Fernández-Villar %T COPD and lung cancer: Prevalence, infradiagnosis, phenotypes and multidimensional characterization %D 2016 %R 10.1183/13993003.congress-2016.PA2792 %J European Respiratory Journal %P PA2792 %V 48 %N suppl 60 %X INTRODUCTION AND OBJECTIVES: Although there is an association between Lung Cancer (LC) and COPD (Chronic Obstructive Pulmonary Disease) there are few data about the grade of coexistence, COPD infradiagnosis, phenotypes and multidimensional parameters. The aims of this study were to determine these issues.METHODOLOGY: Prospective observational multicenter study divided in two substudies. Substudy 1 is descriptive and analyzed patients with LC and COPD concomitant. Subestudy 2 is a case-control comparative in which cases are LC with concomitant COPD (LC-COPD) individuals and controls COPD with no evidence of LC.RESULTS: From January 2014-July 2015 were included 498 LC, 78.7% male, age 68 (10). COPD was diagnosed in 214 (43%) being the underdiagnosis of 67.8%. After multivariate analysis, LC-COPD were older [OR: 1.06; 95%CI (1.03-1.1), p<0.001], active smokers [OR: 2.43; 95%CI (1.34-4.4), p= 0.003], higher rates years/package [OR 1.01 95%CI (1-1.02), p=0.03] and Squamous type [OR: 2.08 95%CI (1.16-3.89), p=0.02]. LC-COPD patients were compared with 138 COPD controls. After multivariate analysis patients with LC-COPD had fewer exacerbations in the last year [OR 0.6 95%CI (0.43-0.9), p=0.01], lower DLCO% [OR: 0.96 95%CI (0.95-0.98), p=0.001] and greater comorbidity (Charlson Index) [OR: 1.47 95%CI (1.21-1.7, p<0.001)].CONCLUSION: The prevalence of COPD in patients with LC is 43% and there is high level of underdiagnosis (67.8%).LC-COPD patients are more frequently scamous type and related to smoking and aging. COPD patients with increased morbidity, less exacerbations and lower DLCO values could be a higher risk group of LC.Study founded by Menarini group. %U