PT - JOURNAL ARTICLE AU - Christina Pearce AU - Anja Jochmann AU - Andrew Bush AU - Robert Horne AU - Louise Fleming TI - Patterns of nonadherence in children with severe asthma AID - 10.1183/13993003.congress-2016.PA3349 DP - 2016 Sep 01 TA - European Respiratory Journal PG - PA3349 VI - 48 IP - suppl 60 4099 - http://erj.ersjournals.com/content/48/suppl_60/PA3349.short 4100 - http://erj.ersjournals.com/content/48/suppl_60/PA3349.full SO - Eur Respir J2016 Sep 01; 48 AB - Introduction: Nonadherence to prescribed medication significantly contributes to poor asthma control. Electronic monitoring devices (Smartinhalers®) have been used to monitor children's adherence and have shown that even when monitored over half of patients had poor adherence of <80% (ERJ1915;46 (suppl 59),OA4775). From a clinical perspective it is plausible that although patients do not adhere fully to their inhalers they may take at least once dose per day.Aims: To assess patterns of nonadherence in children with severe asthma including the proportion of days when preventer inhaler doses were taken once daily.Methods: Secondary analysis was conducted using SmartInhaler® data. Children's adherence to preventer inhalers was monitored in 91 participants (median age=12 years old; range 5-17), over a period of up to 200 days (median 92 days). Participants were prescribed at least one puff of their inhaler twice daily.Results: The median adherence to the prescribed dose was 74% (range 21-99%). No patients took their inhalers as prescribed every day. However, if we apply a cut of >80% adherence, then 52% would be classed as being nonadherent. When assessing once daily use only 12% took their inhaler at least once daily every day. When applying a cut of >80% of the time one third of patients (32%) were still nonadherent to at least a once daily dose.Conclusions: Children take their inhalers less than prescribed, however around two thirds take it at least once per day (>80% of the time). We do not know how or whether a once a daily treatment might affect nonadherence as part of an adherence support package. Further studies investigating the reasons for nonadherence and the acceptability of once daily inhalers are now justified.