RT Journal Article
SR Electronic
T1 Uncontrolled non-heart-beating donors vs. brain dead donors in lung transplantation: Comparison of early and late results
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA4642
DO 10.1183/13993003.congress-2016.PA4642
VO 48
IS suppl 60
A1 Daniel Valdivia Concha
A1 David Gomez De Antonio
A1 Lucas Hoyos Mejía
A1 Jose Luis Campo-Cañaveral
A1 Andres Varela de Ugarte
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA4642.abstract
AB Introduction: The scarcity of grafts remains to be the major limitation in lung transplantation. Uncontrolled non-heart-beating donors (UNHBDs) represent one way to alleviate this problem.Objectives: We present the early and late results of lung transplantation from UNHBDs and compare the outcomes with the recipient cohort receiving lungs from brain dead donors (BDDs).Methods: Between January 2002 and December 2012, 38 (11.5%) of the 330 lung transplantation performed in our institution used lungs from UNHBDs. Early and late outcomes for this recipient cohort were compared with those for recipients who received organs from BBDs (292 patients) over a median follow up of 41.7 months (0.3-133) for UNHBDs and 41 months (0.3-142.3) for BDDs (NS).Results: The incidence of primary graft dysfunction grade 3 (PGD3) in the UNHBDs group was similar to that of the BDDs group (p=0.17). The patient survival rates at 3 months, 1 year, 3, 5 and 10 years were 81.6%, 71.1%, 60.3%, 50.8% and 16.5% for the UNHBDs group and 80.5%, 75%, 66%, 58.4% and 38.1% for the BDDs groups (NS). Freedom from chronic lung allograft dysfunction (CLAD) at 1, 3, 5 and 10 years in the UNHBDs group was 96.3%, 76.6%, 54% and 27% respectively, and did not differ from the incidence of CLAD in the BDDs group (p=0.49).Conclusions: In our experience, both early and late results in UNHBDs lung transplantation were comparable to those with BDDs. Our findings support that the use of lungs from UNHBDs is safe and could substantially expand the donor pool for lung transplantation.