TY - JOUR T1 - Decision analytic models in COPD/asthma: A critical review of current evidence JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2016.PA1532 VL - 48 IS - suppl 60 SP - PA1532 AU - Vaibhav Gaur AU - Jaideep Gogtay AU - Probit Ghosh Y1 - 2016/09/01 UR - http://erj.ersjournals.com/content/48/suppl_60/PA1532.abstract N2 - Asthma and COPD exert a substantial economic and humanistic burden on society, with newer drugs increasingly adding to the burden. . Health economic models used to establish the differential value of newer drugs are often used, but infrequently reviewed.We synthesized evidence pertaining to economic models drugs treating asthma or chronic obstructive pulmonary disease (COPD).Comprehensive search strategies containing terms “Chronic Obstructive”, OR “asthma”, AND “economic models”, and combinations thereof were devised and were used to search Pubmed. The data pertaining to validation methods, treatments compared, analytic perspective, time horizon, input ranges, costs, sensitivity analyses were abstracted. The studies were also critically evaluated using quality of health economic scale (QHES) to determine the methodological appropriateness, robustness of the parameters and other attributes of the model.Evidence was synthesized from 39 and 14 articles associated with asthma and COPD respectively. Economic evaluations included predictive decision-analytic type models, decision trees, and Markov models. Validation of the models regarding internal, external or predictive validity was not frequently reported. The QHES score ranged from 70 to 95, indicating moderate to good quality of the decision analytic evaluations. The overarching evidence indicated a need for empirical decision analytic models suited to closely replicate clinical progression and capture economic/budgetary impact of novel therapies.Current economic models possess moderate to good quality of decision analytics. It remains to be seen whether there could be further improvements in the newer models. ER -