RT Journal Article
SR Electronic
T1 Can neutrophil to lymphocyte ratio be used as infection marker in COPD patients with chronic respiratory failure
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP OA1785
DO 10.1183/13993003.congress-2016.OA1785
VO 48
IS suppl 60
A1 Eylem Acarturk Tuncay
A1 Emine Aksoy
A1 Cuneyt Salturk
A1 Sinem Gungor
A1 Nezihe Ciftaslan Goksenoglu
A1 Dilek Yavuz
A1 Ozlem Yazicioglu Mocin
A1 Gokay Gungor
A1 Nalan Adiguzel
A1 Zuhal Karakurt
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/OA1785.abstract
AB COPD exacerbations lead to frequent hospital admissions in patients with chronic respiratory failure(CRF).Symptoms with complete blood count(CBC) and C-reactive protein(CRP) levels constitutes the cornerstone of clinical evaluation.We aimed to investigate whether Neutrophil to Lymphocyte ratio(NLR) can be used as infection marker in COPD patients with CRF.Method: Retrospective cohort study enrolled in intensive care unit of tertiary training hospital between 2014-2015.Patients admitted the outpatient clinic with CRF due to COPD and CBC included .We defined modified COPD exacerbation attacks due to infection and divided patients as:Exacerbation A:WBC>12000/mm3,CRP>10 mg/dl,Exacerbation B:WBC>10000/mm3,CRP>10mg/dl,Exacerbation C:WBC>10000/mm3,CRP>8 mg/dl,Exacerbation D:WBC>10000/mm3,CRP>5mg/dl.Patients grouped according to peripheral eosinophilia(PE)(≥,<2%) and NLR(10 binary groupings with cut-off values staring from2to10).Exacerbation models(EM),CRP levels,NLR groups compared.Results: 1066 patients with mean age and standard deviation of 66±13.Four EMs significantly correlated with the exacerbation at the cut-off value of NLR: 3.5(p<0.001).Infection rate was higher in the EM A.Ratio of patients with PE< 2% in NLR≥3.5 group were higher significantly in all Ems. (p<0.001)There was significant correlation in patients Exacerbation A with PE≥2 with NLR groups categorized with cut off value of 3.5 (p>0.016).Conclusion: NLR ratio higher than 3.5 is as important as high leucocyte and CRP levels in evaluation of COPD exacerbations in patients with CRF.NLR above and equal 3.5 in patients with PE<%2 suggests primarily infectious etiology and antibiotic treatment should be considered.