RT Journal Article
SR Electronic
T1 Real-life assessment of the multidimensional nature of dyspnoea in COPD outpatients
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1668
OP 1679
DO 10.1183/13993003.01998-2015
VO 47
IS 6
A1 Capucine Morélot-Panzini
A1 Hélène Gilet
A1 Bernard Aguilaniu
A1 Philippe Devillier
A1 Alain Didier
A1 Thierry Perez
A1 Christophe Pignier
A1 Benoit Arnould
A1 Thomas Similowski
YR 2016
UL http://erj.ersjournals.com/content/47/6/1668.abstract
AB Dyspnoea is a prominent symptom of chronic obstructive pulmonary disease (COPD). Recent multidimensional dyspnoea questionnaires like the Multidimensional Dyspnea Profile (MDP) individualise the sensory and affective dimensions of dyspnoea. We tested the MDP in COPD outpatients based on the hypothesis that the importance of the affective dimension of dyspnoea would vary according to clinical characteristics.A multicentre, prospective, observational, real-life study was conducted in 276 patients. MDP data were compared across various categories of patients (modified Medical Research Council (mMRC) dyspnoea score, COPD Assessment Test (CAT) score, Global Initiative for Chronic Obstructive Lung Disease (GOLD) airflow obstruction categories, GOLD “ABCD” categories, and Hospital Anxiety and Depression Scale (HADS)). Univariate and multivariate regressions were conducted to explore factors influencing the affective dimension of dyspnoea. Cluster analysis was conducted to create homogeneous patient profiles.The MDP identified a more marked affective dimension of dyspnoea with more severe mMRC, CAT, 12-item Short-Form Health Survey mental component, airflow obstruction and HADS. Multivariate analysis identified airflow obstruction, depressive symptoms and physical activity as determinants of the affective dimension of dyspnoea. Patients clustered into an “elderly, ex-smoker, severe disease, no rehabilitation” group exhibited the most marked affective dimension of dyspnoea.An affective/emotional dimension of dyspnoea can be identified in routine clinical practice. It can contribute to the phenotypic description of patients. Studies are needed to determine whether targeted therapeutic interventions can be designed and whether they are useful.The affective dimension of dyspnoea can be assessed in COPD outpatients and could help personalise treatment http://ow.ly/YHRiW