TY - JOUR T1 - Outcome of patients with right heart thrombi: the Right Heart Thrombi European Registry JF - European Respiratory Journal JO - Eur Respir J SP - 869 LP - 875 DO - 10.1183/13993003.00819-2015 VL - 47 IS - 3 AU - Marcin Koć AU - Maciej Kostrubiec AU - Waldemar Elikowski AU - Nicolas Meneveau AU - Mareike Lankeit AU - Stefano Grifoni AU - Agnieszka Kuch-Wocial AU - Antoniu Petris AU - Beata Zaborska AU - Branislav S. Stefanović AU - Thomas Hugues AU - Adam Torbicki AU - Stavros Konstantinides AU - Piotr Pruszczyk Y1 - 2016/03/01 UR - http://erj.ersjournals.com/content/47/3/869.abstract N2 - Our aim was the assessment of the prognostic significance of right heart thrombi (RiHT) and their characteristics in pulmonary embolism in relation to established prognostic factors.138 patients (69 females) aged (mean±sd) 62±19 years with RiHT were included into a multicenter registry. A control group of 276 patients without RiHT was created by propensity scoring from a cohort of 963 contemporary patients. The primary end-point was 30-day pulmonary embolism-related mortality; the secondary end-point included 30-day all-cause mortality. In RiHT patients, pulmonary embolism mortality was higher in 31 patients with systolic blood pressure <90 mmHg than in 107 normotensives (42% versus 12%, p=0.0002) and was higher in the 83 normotensives with right ventricular dysfunction (RVD) than in the 24 normotensives without RVD (16% versus 0%, p=0.038). In multivariable analysis the simplified Pulmonary Embolism Severity Index predicted mortality (hazard ratio 2.43, 95% CI 1.58–3.73; p<0.0001), while RiHT characteristics did not. Patients with RiHT had higher pulmonary embolism mortality than controls (19% versus 8%, p=0.003), especially normotensive patients with RVD (16% versus 7%, p=0.02).30-day mortality in patients with RiHT is related to haemodynamic consequences of pulmonary embolism and not to RiHT characteristics. However, patients with RiHT and pulmonary embolism resulting in RVD seem to have worse prognosis than propensity score-matched controls.Prognosis in patients with PE and RiHT is related to haemodynamic effects of PE, not RiHT morphology http://ow.ly/UCpja ER -