PT  - JOURNAL ARTICLE
AU  - Isabelle Jaussent
AU  - Jean-Paul Cristol
AU  - Benedicte Stengel
AU  - Marie-Laure Ancelin
AU  - Anne-Marie Dupuy
AU  - Alain Besset
AU  - Catherine Helmer
AU  - Karen Ritchie
AU  - Claudine Berr
AU  - Yves Dauvilliers
TI  - Impact of sleep disturbances on kidney function decline in the elderly
AID  - 10.1183/13993003.01147-2015
DP  - 2015 Dec 02
TA  - European Respiratory Journal
PG  - ERJ-01147-2015
4099  - http://erj.ersjournals.com/content/early/2015/12/02/13993003.01147-2015.short
4100  - http://erj.ersjournals.com/content/early/2015/12/02/13993003.01147-2015.full
AB  - While sleep disturbances are frequent in renal disease patients, no studies have examined prospectively the associations between sleep disturbances and kidney function decline in community-dwelling elderly subjects.Glomerular filtration rates (eGFRs) were estimated at baseline and at 11-year follow-up. A glomerular filtration decline over the follow-up period was defined as a percentage decline greater than or equal to the cut-off value of the highest tertile of kidney function decline (22%) in 1105 subjects. Excessive daytime sleepiness (EDS) and insomnia complaints were self-rated at baseline. Restless legs syndrome (RLS) and its age at onset were assessed at study end-point. An ambulatory polysomnography recording was performed during the follow-up in 277 subjects. Apnoea-hypopnoea index (AHI), periodic limb movements during sleep (PLMS) and total sleep time were analysed.An increased risk of eGFR decline was associated with EDS (OR 1.67, 95% CI 1.18–2.34) and RLS (OR 1.98, 95% CI 1.18–3.30) independently of potential confounders including cardiovascular risk factors. Among insomnia complaints, a borderline association with eGFR decline was found for early morning awakening only. High AHI (≥30 events·h−1) and short total sleep time (<6 h), but not PLMS were linked to eGFR decline in crude associations, but only AHI remained significantly associated after multi-adjustments.EDS, RLS and AHI constitute independent risk factors for kidney glomerular function decline.Excessive daytime sleepiness, restless legs syndrome and AHI are risk factors for kidney glomerular function decline http://ow.ly/TtVRr