PT - JOURNAL ARTICLE AU - Mitsuko Kondo AU - Ken Arimura AU - Kiyoshi Takeyama AU - Etsuko Tagaya AU - Jun Tamaoki TI - The clinical significance of 24hr continuous monitoring of SpO<sub>2</sub> during daily life in the patients with interstitial pneumonia AID - 10.1183/13993003.congress-2015.PA3825 DP - 2015 Sep 01 TA - European Respiratory Journal PG - PA3825 VI - 46 IP - suppl 59 4099 - http://erj.ersjournals.com/content/46/suppl_59/PA3825.short 4100 - http://erj.ersjournals.com/content/46/suppl_59/PA3825.full SO - Eur Respir J2015 Sep 01; 46 AB - Background: Exercise-induced hypoxia is a characteristic feature of interstitial pneumonia. Although the patients are not hypoxic at rest, oxygen saturation tends to drop abruptly during exercise.Objectives: The aim of this study is to evaluate the frequency and severity of hypoxia during daily life in the patients with interstitial pneumonia.Methods: Thirteen subjects (male 11, age 68.2 ± 10.4) were recruited from the outpatient clinic of our institute. SpO2 was monitored for 24 hours using ambulatory pulse oximeter, Pulsox-Me300 (Konica-Minolta, Tokyo, Japan). All data were downloaded to a computer for the analysis. While being monitored, patients recorded detailed diary including activities and events.Results: The patients consisted of 6 IPF, 3 NSIP and 4 CVD. The pulmonary function tests were %DLCO 39.0 ± 13.6% and %VC 76.6 ± 16.8%. Average of SpO2 during 24 hours was 93.8 ± 1.6%. Minimal SpO2 was 70.4 ± 17.1%. The frequency of &gt;4% dip was 9.31 ± 5.4 /hour. All patients showed hypoxia during exercise. Two patients played tennis and golf in spite of severe exercise-induced hypoxia. Furthermore, four patients with pulmonary hypertension showed more severe hypoxia with minimal SpO2 59.1 ± 12.6% and the frequency of &gt;4% dip 13.1 ± 4.5 /hour, although two of them had already received home oxygen therapy. In contrast, most of the patients did not show hypoxia during sleep.Conclusions: 24hr continuous monitoring of SpO2 could detect severe exercise-induced hypoxia during daily life in the patients with interstitial pneumonia. Intermittent severe hypoxia may be associated with the progression of pulmonary hypertension.