RT Journal Article
SR Electronic
T1 Biomarkers in COPD- The role of resistin and leptin
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA691
DO 10.1183/13993003.congress-2015.PA691
VO 46
IS suppl 59
A1 Vlasios Vitsas
A1 Kardara Matina
A1 Vasileiou Aliki
A1 Koutsoukou Antonia
A1 Michalopoulou Pinelopi
A1 Orfanos Stylianos
A1 Tsoukalas Georgios
A1 Kotanidou Anastasia
YR 2015
UL http://erj.ersjournals.com/content/46/suppl_59/PA691.abstract
AB Introduction: COPD is a condition of global importance, characterised by accelerated lung function decline and an abnormal inflammatory response. Exacerbations account for much of the morbidity and the mortality in COPD. Leptin is a protein that is synthesised and secreted by white adipose tissue while resistin is a cysteine-rich adipose-derivedpeptide hormone that in humans is encoded by the RETN gene.Objectives: To record and analyse parameters such as biomarkers, lung functions and dyspnea level on the 1st day of a COPD exacerbation, at discharge and 6 weeks after.Methods: 35 patients (mean age 67,5 years) hospitalised for exacerbation of COPD are included so far in the study. Biomarkers such as adiponectin, leptin, resistin, IL6, IL8 and CRP were measured at admission, at discharge and 6 weeks after discharge. Lung function and dyspnea level were studied and measured at discharge and 6 weeks later.Results: Leptin levels at admission (mean=41,28 ng/ml) were decreased at discharge (33,2) (p=0,015) and further decreased 6 weeks after discharge (mean=29,94 and compared to the admission levels p=0,002). Similar results were observed with resistin, (admission levels mean=23,76, discharge levels 17,64 p=0,064 and levels 6 weeks were 11,66 and compared to the admission levels p=0,001).Statistical significant differences were also observed at the levels of CRP at admission and discharge (p<0,001) and at the levels of FEV1 % at discharge and 6 weeks after(p=0,003) as expected.Conclusion: Levels of Leptin and Resistin are found significantly decreased at discharge and 6 weeks after discharge compared to the admission levels fact that indicates that they may be valuable biomarkers for the assessment of COPD severity along with FEV1 and CRP.