@article {TraulsenPA1118, author = {Lisbet Krogh Traulsen and Jesper Baelum and Anders Halling and Trine Thilsing and David Sherson and Torben Sigsgaard and {\O}yvind Omland and Tine Malling and Lars Skadhauge}, title = {Risk factors for new-onset asthma and early COPD in a cohort of young adults}, volume = {46}, number = {suppl 59}, elocation-id = {PA1118}, year = {2015}, doi = {10.1183/13993003.congress-2015.PA1118}, publisher = {European Respiratory Society}, abstract = {Introduction: Asthma and COPD have different pathology, but only few population-based studies have evaluated common risk factors for adult-onset asthma and early COPD.Aims and objectives: The aim of this study was to describe common risk factors for incident asthma and COPD in young adults.Methods: A cohort of 1,191 individuals, age 20{\textendash}44 years, participated in baseline interview and clinical examination within the RAV-study in 2003-2005 including lung function measurement, bronchial challenge and SPT. Re-examination of 747 subjects (63\%) during follow-up in 2013-2014 comprised 459 subjects, who at baseline denied ever having asthma and did not have bronchial obstruction defined by Lower Limit of Normal. End points at follow-up for asthma was defined by self-reported ever having asthma and for COPD a lung function showing bronchial obstruction. Risk estimates of potential determinants measured at baseline were computed by logistic regression.Results: A total of 17 incident cases of asthma and 20 cases of COPD were identified at follow-up corresponding to an incidence rate of 4.4 and 4.7 per 1,000 person years, respectively. Significant risk factors for incidence of asthma were FEV1\<100\% of predicted value (OR 6.17; 95\%CI 1.54-24.74), bronchial hyperresponsiveness (BHR) (OR 4.29; 1.08-17.08), female gender (OR 4.76; 1.40-16.15), and maternal asthma (OR 7.24; 1.66-31.55). For COPD significant risk factors were FEV1\<100\% of predicted (OR 4.94; 1.44-17.00), BHR (OR 5.35; 1.67-17.16), female gender (OR 5.16; 1.62-16.46) and smoking (OR 5.56; 1.85-16.73).Conclusions: FEV1\<100\% of predicted, BHR, and female gender were common risk factors for adult-onset asthma and COPD.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/46/suppl_59/PA1118}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }