RT Journal Article SR Electronic T1 Do anxiety and depression affect different outcomes of pulmonary rehabilitation? JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP PA3723 DO 10.1183/13993003.congress-2015.PA3723 VO 46 IS suppl 59 A1 Latinka Basara A1 Tajana JaluĊĦic Gluncic A1 Olivera Maletic A1 Dubravka Pelicaric A1 Sanja Popovic Grle A1 Marko Jakopovic A1 Miroslav Samarzija YR 2015 UL http://erj.ersjournals.com/content/46/suppl_59/PA3723.abstract AB Introduction: Efficacy of pulmonary rehabilitation program (PRP) in reducing psychological distress has been previously demonstrated. Nevertheless, possible separate and different impact of anxiety and depression on pulmonary rehabilitation outcomes remains unclear.Aim: The aim was to investigate whether anxiety (ANX) and depression (DEP) have different affects on PRP outcomes - six-minute walking test (6MWT), fatigue (F) and dyspnea (DYS).Method: Study included 50 subjects with chronic obstructive respiratory disease. Before PRP they were divided to 4 groups according to DASS21 questionnaire score: normal anxiety level, normal depression level, moderate /severe anxiety level, moderate/severe depression level. All subjects were measured in 6-minute walking test, dyspnea and fatigue (Borg scale) prior to and after three week standard PRP. We observed the difference in measured variables (6MWT,DYS, F) at baseline and after PRP for all subjects and in regards to group division.Results: All measured outcomes have significantly improved after PRP. Elevated ANX at baseline was significantly related to higher dyspnea (p<0.05) and fatigue (p<0.01). Elevated DEP at baseline was significantly related to poorer 6MWT (p<0.05). Elevated ANX did not affect 6MWT and elevated DEP score did not affect dyspnea or fatigue. ANX nor DEP measured after PRP had no affect on 6MWT, DYS or F scores after PRP.Conclusion: Even though all measured variables improve after PRP, elevated anxiety affects dyspnea and fatigue, while elevated depression has a significantly greater effect on 6MWT. This finding could indicate that there are different psychological mechanisms behind different pulmonary rehabilitation outcomes.