TY - JOUR T1 - Determinants of physical activity in patients with COPD: A longitudinal study JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2015.PA3562 VL - 46 IS - suppl 59 SP - PA3562 AU - Tsung Yu AU - Anja Frei AU - Ter Riet Gerben AU - Milo Puhan Y1 - 2015/09/01 UR - http://erj.ersjournals.com/content/46/suppl_59/PA3562.abstract N2 - Background: Although a large body of literature assessed the determinants of physical activity in patients with COPD, most of the studies were cross-sectional and focused on one or few determinants. We aimed to examine the determinants of physical activity using longitudinal models.Methods: In a prospective cohort study, 409 patients with COPD managed by general practitioners in the Netherlands or Switzerland were recruited and followed for 5 years. Patients completed a validated questionnaire (Longitudinal Aging Study Amsterdam Physical Activity Questionnaire) at baseline and every 6 months about their physical activity. We fitted linear mixed models to study the associations between predictors at baseline and physical activity (an adapted score on a 0-23 scale) across all study follow-up visits.Results: Unadjusted analysis suggested that there was a decrease in physical activity over time (coefficient = -0.22 per visit, 95% CI = -0.28, -0.17, p<0.001). In multivariate longitudinal analyses, predictors at baseline independently associated (p≤0.05) with physical activity across all follow-up visits were (from the strongest to weakest predictor) exercise capacity, age, working status, smoking pack years, health related quality of life (fatigue), sex, education, participating in fitness program, symptoms of depression, FEV1, feeling thermometer measure, and number of prescription drugs.Conclusion: We identified in a cohort study several statistically significant determinants of physical activity in patients with COPD. It allows to identify patients who remain having low physical activity and who may benefit particularly from pulmonary rehabilitation that addresses the determinants of physical activity. ER -