RT Journal Article SR Electronic T1 Age as a factor affecting the diagnostic accuracy of TB lymphadenitis JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP PA2759 DO 10.1183/13993003.congress-2015.PA2759 VO 46 IS suppl 59 A1 Kavita Dave A1 Anita Saigal A1 Farhan Ullah A1 Ferduche Miah A1 Hardeep Kalsi A1 Robert Sands A1 Ajitha Jayaratnam YR 2015 UL http://erj.ersjournals.com/content/46/suppl_59/PA2759.abstract AB Introduction: London has a high incidence of TB, and the boroughs served by Barking, Havering, and Redbridge University Hospitals Trust (BHRUT) reflects a high risk population. A recent review of BHRUT TB lymphadenitis cases between 2009 and 2013 revealed more lymph node (LN) samples were sent for histology than microbiology, potentially impacting management of these patients.Aim: To identify whether age affected the diagnostic sampling of lymph nodes in TB lymphadenitis.Method: A retrospective analysis of the investigations performed against the age of the patient, using the London TB Register (LTBR) to identify cases of TB lymphadenitis in BHRUT between 2009 and 2013.Results: 324 patients were identified. Of these, 231 (71.3%) had LN samples sent for histology, and 179 (55.2%) had LN samples sent for microbiology. This was analysed further for each age group (Table 1).View this table:Table 1 Percentage of lymph node samples sent for histology and microbiology in each age groupIn addition, 50-80% of histological samples in each age group were consistent with a diagnosis of TB.Conclusion: In the older population (>60 years), almost all LN samples were sent for histology, indicating that in this cohort of patients, the primary differential is of a histological nature, i.e. cancer, due to their age. This analysis suggests we should change our current multidisciplinary practice by sending all LN samples for microbiological investigation, as in high risk populations, TB should always be a differential for lymphadenitis.