@article {KoblizekPA393, author = {Vladimir Koblizek and Ruzena Tkacova and Attila Somfay and Branislava Milenkovic and Adam Barczyk and Kirill Zykov and Neven Tudoric and Kosta Kostov and Zuzana Zbozinkova and Jan Svancara and Jurij Sorli and Alvis Krams and Marc Miravitlles and Arschang Valipour}, title = {LATE-BREAKING ABSTRACT: Phenotypes of COPD in central and Eastern Europe - The POPE study}, volume = {46}, number = {suppl 59}, elocation-id = {PA393}, year = {2015}, doi = {10.1183/13993003.congress-2015.PA393}, publisher = {European Respiratory Society}, abstract = {Introduction: Chronic obstructive pulmonary disease (COPD) represents a major health problem in Central and Eastern European (CEE) countries. However, data regarding symptom load and clinical phenotypes of patients with COPD in CEE remain largely unknown.Methods: Participation in the POPE Study (a multicentre, observational cross-sectional survey) was offered to consecutive outpatients with stable COPD in 11 CEE countries if they fulfilled the following criteria: age >= 40 years, smoking history >= 10 pack-years, post-bronchodilator (BD) FEV1/FVC \< 0.7 and absence of COPD exacerbation >= 4 weeks.Results: 3504 patients (66 {\textpm} 8.7 yrs, 69\% male, post-BD FEV1 53.0 {\textpm} 17.5\% predicted, Charlson comorbidity index 2.0 {\textpm} 1.4, and 1.2 {\textpm} 1.6 exacerbations within the last 12 months) were recruited between Apr 2014 and May 2015. The majority of patients were classified as GOLD D or GOLD B (57\% and 30.6\% of total, respectively). According to predefined phenotypes, 63\% of the population were non-exacerbators, 20.5\% frequent exacerbators with chronic bronchitis (CB), 9.5\% frequent exacerbators without CB, and 7\% were patients with asthma-COPD overlap syndrome (ACOS). There were statistically significant differences in symptom load and lung function between these phenotypes. NON-exacerbatorsACOSFrequent exacerbators without CBFrequent exacerbators with CBp{\texttwosuperior}CAT total{\textonesuperior}15.8 (7.3){\textasciidieresis}17.8 (7.8){\textasciimacron}18.2 (7.4){\textasciimacron}22.2 (7.5){\textdegree}\<0.001Post-bronchodilator FEV1{\textonesuperior}55.8 (17.3){\textasciimacron}55.0 (17.6){\textasciimacron}45.5 (15.9){\textasciidieresis}47.0 (16.1){\textasciidieresis}\<0.001{\textonesuperior}Mean and standard deviation. {\texttwosuperior}One way ANOVA.{\textasciimacron},{\textasciidieresis},{\textdegree} indicate homogenous groups (Tukey post hoc test).Conclusion: First results of the POPE study offer insight into symptom load, lung function, and phenotypes of COPD in CEE countries.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/46/suppl_59/PA393}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }