RT Journal Article
SR Electronic
T1 Asthma, COPD and overlap syndrome: a longitudinal study in young European adults
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 671
OP 679
DO 10.1183/09031936.00008615
VO 46
IS 3
A1 Roberto de Marco
A1 Alessandro Marcon
A1 Andrea Rossi
A1 Josep M. Antó
A1 Isa Cerveri
A1 Thorarinn Gislason
A1 Joachim Heinrich
A1 Christer Janson
A1 Deborah Jarvis
A1 Nino Kuenzli
A1 Bénédicte Leynaert
A1 Nicole Probst-Hensch
A1 Cecilie Svanes
A1 Matthias Wjst
A1 Peter Burney
YR 2015
UL http://erj.ersjournals.com/content/46/3/671.abstract
AB We compared risk factors and clinical characteristics, 9-year lung function change and hospitalisation risk across subjects with the asthma–chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS), asthma or COPD alone, or none of these diseases.Participants in the European Community Respiratory Health Survey in 1991–1993 (aged 20–44 years) and 1999–2001 were included. Chronic airflow obstruction was defined as pre-bronchodilator forced expiratory volume in 1 s (FEV1)/forced vital capacity<lower limit of normal on both occasions. Based on their history of respiratory symptoms, spirometry and risk factors, subjects were classified as having asthma alone (n=941), COPD alone (n=166), ACOS (n=218) and none of these (n=5659).Subjects with ACOS shared risk factors and clinical characteristics with subjects with asthma alone, but they had an earlier age of asthma onset. FEV1 change in the ACOS group (−25.9 mL·year−1) was similar to that in the asthma group (−25.3 mL·year−1), and lower (p<0.001) than in the COPD group (−37.3 mL·year−1). ACOS was associated with the highest hospitalisation rate.Among young adults aged 20–44 years, ACOS seems to represent a form of severe asthma, characterised by more frequent hospitalisations, and to be the result of early-onset asthma that has progressed to fixed airflow obstruction.The asthma–COPD overlap syndrome in young adults is a form of early-onset severe asthma with recurrent exacerbations http://ow.ly/MHkss