RT Journal Article
SR Electronic
T1 Pulse transit time as a measure of respiratory effort under non-invasive ventilation
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP erj01939-2011
DO 10.1183/09031936.00193911
A1 Olivier Contal
A1 Claudio Carnevale
A1 Jean-Christian Borel
A1 Kébir Sabil
A1 Renaud Tamisier
A1 Patrick Lévy
A1 Jean-Paul Janssens
A1 Jean-Louis Pépin
YR 2012
UL http://erj.ersjournals.com/content/early/2012/04/19/09031936.00193911.abstract
AB Among respiratory events which may occur during nocturnal non-invasive ventilation (NIV), differentiating between central and obstructive events requires appropriate indicators of respiratory effort.To assess pulse transit time (PTT) as an indicator of respiratory effort under NIV in comparison with esophageal pressure (Pes).1: During wakefulness, PTT was compared to Pes during spontaneous breathing and under NIV with or without induced leaks in 11 healthy individuals. 2: Contribution of PTT versus Pes for differentiating central from obstructive respiratory events occurring under NIV during sleep was evaluated in 10 patients with obesity hypoventilation syndrome (OHS).1: From spontaneous breathing to NIV without leaks, respiratory effort decreased significantly whereas, with increasing level of leaks, there was a significant increase in respiratory effort. Changes in PTT accurately reflected changes in Pes. 2: In OHS patients during nocturnal NIV, intraclass correlation coefficients between Pes and PTT were 0.970 for total number of events and 0.970 for percentage of central events.PTT accurately reflects the unloading of respiratory muscles induced by NIV and the increase in respiratory effort during leaks. PTT during sleep is also useful to differentiate central from obstructive respiratory events occurring under NIV.