PT - JOURNAL ARTICLE AU - K. Berhane AU - Y. Zhang AU - W.S. Linn AU - E.B. Rappaport AU - T.M. Bastain AU - M.T. Salam AU - T. Islam AU - F. Lurmann AU - F.D. Gilliland TI - The Effect of Ambient Air Pollution on Exhaled Nitric Oxide in the Children's Health Study AID - 10.1183/09031936.00081410 DP - 2010 Jan 01 TA - European Respiratory Journal PG - erj00814-2010 4099 - http://erj.ersjournals.com/content/early/2010/10/14/09031936.00081410.short 4100 - http://erj.ersjournals.com/content/early/2010/10/14/09031936.00081410.full AB - We assessed the effect of daily variations in ambient air pollutants on exhaled nitric oxide (FeNO) using data from a cohort of schoolchildren with large differences in air pollutant exposures from the Children's Health Study.Based on a cohort of 2240 schoolchildren from 13 Southern California communities, cumulative lagged average regression models were fitted to determine the association between FeNO and ambient air pollution levels from central site monitors with lags of up to 30 days prior to FeNO testing.Daily 24-hr cumulative lagged averages of PM2.5 (over 1–8 days) and PM10 (over 1–7 days), as well as 10AM-6PM cumulative lagged average of O3 (over 1–23 days) were significantly associated with 17.42% (p<0.01), 9.25% (P<0.05) and 14.25% (p<0.01) higher FeNO levels over the inter-quartile range of 7.5 μg·m−3, 12.97 μg·m−3, and 15.42 ppb, respectively. The effects of PM2.5, PM10 and O3 were higher in the warm season. The PM effects were robust to adjustments for effects of O3 and temperature and did not vary by asthma or allergy status.In Summary, short-term increases in PM2.5, PM10, and O3 were associated with airway inflammation independent of asthma and allergy status, with PM10 effects significantly higher in the warm season.