PT  - JOURNAL ARTICLE
AU  - C. Carlsten
AU  - M. Brauer
AU  - H. Dimich-Ward
AU  - A. Dybuncio
AU  - A.B. Becker
AU  - M. Chan-Yeung
TI  - Combined exposure to dog and indoor pollution: incident asthma in a high-risk birth cohort
AID  - 10.1183/09031936.00187609
DP  - 2010 Jan 01
TA  - European Respiratory Journal
PG  - erj01876-2009
4099  - http://erj.ersjournals.com/content/early/2010/06/07/09031936.00187609.short
4100  - http://erj.ersjournals.com/content/early/2010/06/07/09031936.00187609.full
AB  - The impact of single exposures on asthma development is better understood than is the effect of multiple exposures.Evaluate effect of combined early exposure to dog allergen (Can-f1) plus indoor nitrogen dioxide (NO2) or environmental tobacco smoke (ETS) on asthma and bronchial hyperreactivity (BHR) in a high-risk birth cohort; assess atopy's impact on these exposures' effects.Peri-birth ETS exposure was measured using cord blood cotinine (CCot). During year 1, atopy, NO2, Can-f1, and urinary cotinine:Cr (UCot) were measured. At age seven, 380 children were assessed for asthma and BHR. Exposure effects were determined by stepwise multiple linear regression.Co-exposure to elevated Can-f1 and NO2, or Can-f1 and ETS (CCot), increased risk for asthma, relative to having neither such exposure (OR =4.8 [1.1–21.5], 2.7 [1.1–7.1] respectively); similar risks resulted when substituting dog ownership for allergen. Atopy increased asthma and BHR risk associated with several exposures; notably, atopy with elevated UCot, relative to atopy without such exposure, increased risk of BHR (OR =3.1 [1.1–8.6]).In a high-risk birth cohort, early co-exposure to dog allergen and NO2 or ETS increased risk for incident asthma; atopy increased risk of asthma and BHR associated with ETS.