PT  - JOURNAL ARTICLE
AU  - J.L. Hook
AU  - S.M. Arcasoy
AU  - D. Zemmel
AU  - M. Bartels
AU  - S.M. Kawut
AU  - D.J. Lederer
TI  - Titrated oxygen requirement and prognostication in idiopathic pulmonary fibrosis
AID  - 10.1183/09031936.00108111
DP  - 2011 Jan 01
TA  - European Respiratory Journal
PG  - erj01081-2011
4099  - http://erj.ersjournals.com/content/early/2011/09/01/09031936.00108111.short
4100  - http://erj.ersjournals.com/content/early/2011/09/01/09031936.00108111.full
AB  - The supplemental oxygen flow rate is a common bedside measure of gas exchange impairment. We aimed to determine whether a titrated oxygen requirement predicted mortality in idiopathic pulmonary fibrosis.We examined 104 adults with idiopathic pulmonary fibrosis enrolled in a prospective cohort study and a validation cohort of 151 adults with a variety of interstitial lung diseases. The titrated oxygen requirement was defined as the lowest oxygen flow rate required to maintain an oxyhemoglobin saturation of 96% while standing. Cox proportional hazards models and time-dependent receiver operating characteristic curves were used to examine survival time.A higher titrated oxygen requirement was associated with a greater mortality rate independent of forced vital capacity and six-minute walk test results in idiopathic pulmonary fibrosis (adjusted hazard ratio per 1 L·min−1=1.10, 95% confidence interval 1.01 to 1.20). The titrated oxygen requirement was at least as accurate as pulmonary function and six-minute walk testing at predicting 1-year mortality. Findings were similar in other interstitial lung diseases.The titrated oxygen requirement is a simple, inexpensive bedside measurement that aids prognostication in idiopathic pulmonary fibrosis.