RT Journal Article
SR Electronic
T1 Clinical presentation and outcome of venous thromboembolism in chronic obstructive pulmonary disease
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP erj00588-2011
DO 10.1183/09031936.00058811
A1 L. Bertoletti
A1 S. Quenet
A1 P. Mismetti
A1 L. Hernández
A1 J.J. Martín-Villasclaras
A1 C. Tolosa
A1 M. Valdés
A1 M. Barrón
A1 J.A. Todolí
A1 M. Monreal
A1 the RIETE Investigators
YR 2011
UL http://erj.ersjournals.com/content/early/2011/09/01/09031936.00058811.abstract
AB Chronic Obstructive Pulmonary Disease (COPD) is a moderate risk factor for venous thromboembolism (VTE), but neither the clinical presentation nor the outcome of VTE in COPD patients is well known.The clinical presentation of VTE, namely pulmonary embolism (PE) or deep venous thrombosis (DVT) and the outcome at 3 months (death, recurrent VTE or bleeding) were compared between 2984 COPD patients and 25936 non-COPD patients included in the RIETE registry. This ongoing international multicentre registry includes patients with proven symptomatic PE or DVT.PE was the more frequent VTE presentation in COPD patients (1761, 59%). PE presentation was significantly more associated with COPD patients than with non-COPD patients (OR: 1.64 [1.49 – 1.80]). During the 3-month follow-up, mortality (10.8% vs 7.6%), minor bleeding (4.5% vs 2.3%) or first VTE recurrences as PE (1.5% vs 1.1%) were significantly higher in COPD patients than in non-COPD patients. PE was the first cause of death.COPD patients presented more frequently with PE than with DVT. It may explain the worse prognosis of COPD patients, with a higher risk of death, bleeding or VTE recurrences as PE compared with non-COPD patients. Further therapeutic options are needed.