TY - JOUR T1 - Outcomes of hospitalization for right heart failure in pulmonary arterial hypertension JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/09031936.00148310 SP - erj01483-2010 AU - A. Campo AU - S.C. Mathai AU - J. Le Pavec AU - A.L. Zaiman AU - L.K. Hummers AU - D. Boyce AU - T. Housten AU - N. Lechtzin AU - H. Chami AU - R.E. Girgis AU - P.M. Hassoun Y1 - 2011/01/01 UR - http://erj.ersjournals.com/content/early/2011/02/10/09031936.00148310.abstract N2 - To examine the causes and outcomes of hospitalization in patients with pulmonary arterial hypertension (PAH).205 consecutive hospitalizations from 2000 to 2009 in 90 PAH patients.The leading causes for hospitalization were right heart failure (RHF) (56%), infection (16%), and bleeding disorders (8%). For patients with RHF, in-hospital mortality was 14% overall, 46% for patients receiving inotropes, and 48% for those admitted to the ICU. The predictors for in-hospital mortality were the presence of connective tissue disease (CTD) (OR 4.92;P=0.03), systolic blood pressure<100 (OR 4.32;P=0.01) and Na<=136 (OR 4.29;P=0.02). Mortality after discharge was 13%, 26% and 35% at 3, 6 and 12 months. WHO functional class prior to admission, renal dysfunction, Charlson comorbidity index, and the presence of CTD were all predictors of mortality after discharge.Hyponatremia and low systolic blood pressure upon admission, and underlying CTD are the main prognostic factors for in-hospital mortality in patients with PAH admitted for RHF. The short term outcomes after discharge are poor and remarkably worse in patients with underlying CTD or renal impairment. Early recognition of these factors may guide decision regarding more aggressive therapy including consideration for lung transplantation. ER -