TY - JOUR T1 - CT Score and Pulmonary Function in Infants with Chronic Lung Disease of Infancy JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/09031936.00172310 SP - erj01723-2010 AU - E.E. Sarria AU - R. Mattiello AU - L. Rao AU - M.R. Wanner AU - M.E. Raske AU - C. Tiller AU - R. Kimmel AU - R.S. Tepper Y1 - 2011/01/01 UR - http://erj.ersjournals.com/content/early/2011/04/07/09031936.00172310.abstract N2 - Chronic lung disease of Infancy (CLDI) remains a common outcome among infants born extremely premature. In older children and adults with lung disease, pulmonary function and computed tomography (CT) scores are used to follow-up respiratory disease and assess disease severity. For infants and toddlers, these outcomes have been used very infrequently and most often a dichotomous respiratory outcome (presence or absence of CLDI) is employed. We evaluated the performance of CT score and pulmonary function to differentiate infants and toddlers with CLDI from a control group.CT scans, forced expiratory flows, and pulmonary diffusing capacity were obtained in 39 CLDI and 41 Controls (4–33 months of age). CT scans were quantified using a scoring system, while pulmonary function was expressed as Z-scores. CT score outperformed pulmonary function in identifying those with CLDI. There were no significant correlations between CT score and pulmonary function.CT score had a better performance than pulmonary function; however, these outcomes may reflect differing components of the pulmonary pathophysiology of CLDI. This new information on pulmonary outcomes can assist in designing studies with these parameters. Future studies will be required to evaluate which of the outcomes can better detect improvement with therapeutic intervention and/or lung growth. ER -