RT Journal Article
SR Electronic
T1 The respiratory health effects of nitrogen dioxide (NO2) in children with asthma
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP erj01154-2009
DO 10.1183/09031936.00115409
A1 J. Gillespie-Bennett
A1 N. Pierse
A1 K. Wickens
A1 J. Crane
A1 P. Howden-Chapman
A1 and the Housing, Heating and Health Study Research Team
YR 2010
UL http://erj.ersjournals.com/content/early/2010/12/22/09031936.00115409.abstract
AB The impact of NO2 on the respiratory health of children with asthma was explored as a secondary analysis of a randomised community trial, involving 409 households over the 2006 winter period (June to September). Geometric mean indoor NO2 levels were 11.4μg·m−3, while outdoor NO2 levels were 7.4μg·m−3. Higher indoor NO2 levels (per logged unit increase) were associated with greater daily reports of lower (change in mean symptom rate per unit increase in NO2 1.14: 95% CI 1.12–1.16) and upper respiratory tract symptoms (change in mean symptom rate per unit increase in NO2 1.03: 95% CI; 1.00–1.05) more frequent cough and wheeze and more frequent reliever use during the day, but had no effect on preventer use. Higher indoor NO2 levels (per logged unit increase) were associated with a decrease in morning (−17.25mls: 95% CI −27.63 to −6.68) and evening (−13.21: 95% CI −26.03 to −0.38) FEV1 readings. Outdoor NO2 was not associated with respiratory tract symptoms, asthma symptoms, medication use, or lung function measures. These findings indicate that reducing NO2 exposure indoors is important in improving the respiratory health of children with asthma.