RT Journal Article
SR Electronic
T1 Surfactant protein-B polymorphisms, pulmonary function and COPD in 10,231 individuals
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP erj00264-2010
DO 10.1183/09031936.00026410
A1 M. Bækvad-Hansen
A1 B.G. Nordestgaard
A1 M. Dahl
YR 2010
UL http://erj.ersjournals.com/content/early/2010/08/06/09031936.00026410.abstract
AB The surfactant protein-B (SP-B) gene may influence COPD and thus personalised medicine. We tested whether functional polymorphisms in SP-B (rs1130866=1580T>C, rs2077079= −18A>C and rs3024791= −384G>A) associate with reduced lung function and risk of COPD in the general population.We genotyped 10,231 individuals from the adult Danish general population, and recorded spirometry and hospital admissions due to COPD. Because we previously found an association between the rare SP-B 121ins2 mutation and COPD among smokers, we stratified the analyses for smoking status.None of the individual SP-B genotypes or genotype combinations were associated with reduced FEV1%predicted, FVC%predicted and FEV1/FVC overall, or among smokers separately (p=0.25–0.99). The odds ratio for spirometry defined COPD did not differ from 1.0 for any of the SP-B genotypes or genotype combinations overall, or among smokers separately (p=0.17 to 0.78). Similar results were obtained for hospitalisation due to COPD (p=0.07 to 0.93); we could exclude overall hazard ratios for heterozygotes of 1.18 to 1.21 and for homozygotes of 1.25 to 1.57 or larger for all three polymorphisms.In conclusion, functional polymorphisms in the SP-B gene are not associated with reduced lung function or risk of COPD, making it unlikely that these variants will be useful in personalised medicine.