RT Journal Article
SR Electronic
T1 Influenza vaccination is associated with reduced severity of community acquired pneumonia
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP erj01335-2010
DO 10.1183/09031936.00133510
A1 A. Tessmer
A1 T. Welte
A1 R. Schmidt-Ott
A1 S. Eberle
A1 G. Barten
A1 N. Suttorp
A1 Tom Schaberg
A1 for the CAPNETZ study group
YR 2011
UL http://erj.ersjournals.com/content/early/2010/12/09/09031936.00133510.abstract
AB Pneumonia is an important cause of influenza-associated morbidity and mortality. Influenza vaccination has been shown to reduce morbidity and mortality during influenza-seasons. Protection from severe pneumonia may contribute to the beneficial effect of influenza vaccination. Therefore we investigated the impact of prior influenza vaccination on disease severity and mortality in patients with CAP.Analysis from an observational, multicenter cohort study initiated by the German competence network for community acquired pneumonia was performed. Patients were analysed separately as an influenza season and off-season cohort. Associations between vaccination status and outcome parameters were evaluated by multivariate analyses.In the season cohort (2368 patients) CAP in vaccinated patients was significantly less severe according to most of analysed parameters (OR for CURB [≥1] 0.76 (95% CI: 0.60–0.98); for procalcitonin [≥2.0 ng·mL−1] 0.53 (CI: 0.35–0.81), for procalcitonin [≥0.5 ng·mL−1] 0.71 (CI: 0.51–0.99)) and these patients showed a significantly better overall survival within the 6-month follow-up period (HR 0.63, CI: 0.45–0.89). Within the off-season cohort (2632 patients) there was no significant influence of vaccination status on CAP severity or disease outcome.In conclusion, prior influenza vaccination was associated with less severe clinical course and improved overall long-term survival in patients with CAP during influenza-seasons.